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Understanding Hyperthermic Intrathoracic Chemotherapy (HITHOC)

Hyperthermic Intrathoracic Chemotherapy (HITHOC) is an advanced therapeutic approach designed to treat cancers within the chest cavity, particularly mesothelioma and metastatic pleural carcinomatosis. This innovative treatment combines surgery and chemotherapy, offering a targeted and effective solution for cancers that are otherwise challenging to manage.

The Procedure: A Combination of Surgery and Chemotherapy

HITHOC begins with a surgical intervention to remove visible tumor masses within the thoracic cavity. Once the resection is complete, heated chemotherapy agents are introduced into the chest cavity. The elevated temperature enhances the effectiveness of the drugs by improving their penetration into tissues and directly killing residual cancer cells, reducing the likelihood of recurrence.

Enhanced Drug Efficacy Through Hyperthermia

The heating of chemotherapy drugs to a specific temperature during HITHOC has been shown to increase their cytotoxicity. Hyperthermia not only boosts the effectiveness of the drugs but also selectively targets cancer cells, sparing healthy tissues. This targeted approach minimizes systemic side effects, providing a better quality of life for patients.

Suitable Candidates for HITHOC

HITHOC is primarily recommended for patients with cancers confined to the chest cavity, such as malignant pleural mesothelioma, advanced thymoma, and secondary pleural carcinomatosis. It is most effective when the disease is localized, and there is no evidence of widespread metastasis. Comprehensive evaluations, including imaging and diagnostic tests, help determine a patient's suitability for the procedure.